Studies

Phenhermine HCL active ingredient chakkarakolli a.k.a. Gymnema has been shown in research to support weight loss, appetite suppression plus improved glucose metabolism. Below are studies demonstrating the amazing properties of the diet pill active ingredient:

Studies abstracts courtsey of:  U.S. National Library of Medicine National Institutes of Health

Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal.

Luo H, Kashiwagi A, Shibahara T, Yamada K.   Mol Cell Biochem. 2007 May;299(1-2):93-8.   PMID:  16691318

Mol Cell Biochem. 2007 May;299(1-2):93-8.

Department of Pathophysiological and Therapeutic Science, Division of Medical Biochemistry, Faculty of Medicine, Tottori University, Yonago, 683-8503, Japan. luo_jsps @ hotmail . com

Abstract

OBJECTIVE: The aim of this work was to find obesity control method without rebound. In our previous studies, gymnemate extracted from Gymnema sylvestre, inhibited oleic acid absorption. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a genetic multifactor syndrome model, exhibits progressive overweight, hyperlipidemia and hyperglycemia. The effect of gymnemate on obesity in OLETF was investigated.

METHODS: Three groups were divided (n=4-8): (1) OLETF-gymnemate, gymnema water extract (containing gymnemate) diet (62.5 g/kg) and water (2.5 g/kg) were supplied 2 weeks from 26-28 weeks, following it general diet and water were fed 3 weeks to observe if it rebound, (2) OLETF-control and (3) the counterpart Long-Evans Tokushima Otsuka rats as normal-control.

RESULTS: With gymnemate treatment, the food and water intake were decreased about 1/3 and 2/3, along with body weight reduced 57.2+/- 6.4 and 75.5+/- 6.3 g during 1 and 2 weeks respectively. The total cholesterol was decreased about 1/3, moreover LDL+VLDL (low-density and very-low-density lipoprotein) cholesterol decreased about 1/2. The proportion of HDL (high-density lipoprotein) cholesterol to the total cholesterol was increased. The serum triglyceride was decreased to the 1/4 of OLETF control.

CONCLUSION: Supplementation with gymnemate promoted weight loss by its ability to reduce hyperlipidemia, which was no withdrawal rebound: an important discovery. Supplementation with gymnemate is a novel therapeutic tool for weight management, especially in multifactor syndrome.


Studies courtsey of:  U.S. National Library of Medicine National Institutes of Health

Diabetes Obes Metab. 2004 May;6(3):171-80.  MID: 15056124 [PubMed – indexed for MEDLINE]

Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss.

Preuss HG, Bagchi D, Bagchi M, Rao CV, Dey DK, Satyanarayana S.  Department of Physiology and Biophysics, Georgetown University Medical Center, Georgetown, Washington, DC 20057, USA. Diabetes Obes Metab. 2004 Nov;6(6):458-9; author reply 460-1.

Abstract

AIM: The efficacy of optimal doses of highly bioavailable (-)-hydroxycitric acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites. HCA-SX has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has demonstrated its ability to maintain healthy insulin levels, while GSE has been shown to regulate weight loss and blood sugar levels.

METHODS: A randomized, double-blind, placebo-controlled human study was conducted in Elluru, India for 8 weeks in 60 moderately obese subjects (ages 21-50, BMI >26 kg/m(2)). Subjects were randomly divided into three groups. Group A was administered HCA-SX 4667 mg, group B was administered a combination of HCA-SX 4667 mg, NBC 4 mg and GSE 400 mg, while group C was given placebo daily in three equally divided doses 30-60 min before meals. All subjects received a 2000 kcal diet/day and participated in supervised walking.

RESULTS: At the end of 8 weeks, body weight and BMI decreased by 5-6% in both groups A and B. Food intake, total cholesterol, low-density lipoproteins, triglycerides and serum leptin levels were significantly reduced in both groups, while high-density lipoprotein levels and excretion of urinary fat metabolites increased in both groups. A marginal or non-significant effect was observed in all parameters in group C.

CONCLUSION: The present study shows that optimal doses of HCA-SX and, to a greater degree, the combination of HCA-SX, NBC and GSE can serve as an effective and safe weight-loss formula that can facilitate a reduction in excess body weight and BMI, while promoting healthy blood lipid levels.


Biol Pharm Bull. 2001 Jun;24(6):713-7.   PMID: 11411567 [PubMed – indexed for MEDLINE]

Effect of administration with the extract of Gymnema sylvestre R. Br leaves on lipid metabolism in rats.

Shigematsu N, Asano R, Shimosaka M, Okazaki M.   Biosci. Textile Technol., Shinshu University, Ueda, Nagano, Japan. noshigematsu@fancl.co.jp

Abstract

Extract of Gymnema sylvestre R. Br leaves (GE) was orally administered once a day to rats fed a high fat diet or normal fat diet for 3 weeks to investigate its influence on lipid metabolism. As a result, GE did not influence body weight gain or feed intake in both diet groups during the experimental period. The apparent fat digestibility was significantly decreased by GE in both diet groups for the last 2 weeks of the experimental period, though not the apparent protein digestibility. In addition, the excretion of neutral sterols and acid steroids into feces was increased by GE in both diet groups. Furthermore, GE decreased the total cholesterol and triglyceride levels in serum. On the other hand, blood lecithin-cholesterol acyltransferase (LCAT) activity was increased by GE. Moreover, it was suggested that GE influenced cecal fermentation and that propionic acid and acetic acid contents in cecum were significantly increased by GE. Consequently, it was suggested that GE improved serum cholesterol and triglyceride levels through influence over a wide range of lipid metabolism in rats.


Comp Biochem Physiol A Comp Physiol. 1991;100(2):309-14.   PMID: 1685952 [PubMed – indexed for MEDLINE]

A novel peptide isolated from the leaves of Gymnema sylvestre–I. Characterization and its suppressive effect on the neural responses to sweet taste stimuli in the rat.

Imoto T, Miyasaka A, Ishima R, Akasaka K.   Department of Physiology, Tottori University School of Medicine, Yonago, Japan.

Abstract

A new substance that suppressed selectively the neural responses of the rat to sweet taste stimuli was isolated from the leaves of Gymnema sylvestre. 2. The substance was proved to be a peptide consisting of 35 amino acids and having a molecular weight of about 4,000. 3. The inhibitory effect on the sweet responses appeared after treating the tongue surface with the peptide at a concentration of more than 1 x 10(-6) M.

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